Ectris and Female Hypoactive Sexual Desire Disorder bring with it more topics for discussion than its male counterpart Erectile Dysfunction. ED and treatments for in men is based more on blood flow to the male sexual organ allowing it to perform intercourse. With Female HSDD, there can be more emotional and metal issues that can get in the way of a woman desiring sexual encounters. Regardless if 1-2 in 10 women experience HSDD to some form and they can't figure out why their sexual desire decreased so much why not a pill that can help if it is available?
There is a fix for men, why not a fix for women? Woman desire the same kind of sexual satisfaction that males do but woman's sexual make up substantially differs from men's. Men can generally be sexually turned on quickly where as with woman it usually takes more time. While HSDD in men is relatively low, in women then numbers are larger and it can be a factor that interferes with her ability to connect to her partner. Sex is a way to connect to your partner for a woman, if there is something that can increase the desire to do this, it could be a fascinating thing. Obviously a substance like Ectris would have to be taken as recommended by a medical doctor and like any drug in existence, to only be taken if it is prescribed to you.
Ectris has the ability to make many women run to their doctors and want to be put on it. Whatever the reasons for causing Female HSDD, a once a day pill could really provide the spark in a woman's love life. There is debate what causes female sexual problems but they often stem from issues to do with ones schedule. For some women, between a job, children, household chores and the stresses that come with them it can be easy to become burnt out and not feel like having any sexual relations with your partner. But others argue that some women in these situations are not affected so it could be genetic or unknown reasons why there is a chemical imbalance. And of course there could be relational issues preventing sexual feelings.
An important point to make with the argument for medical treatment of HSDD is that it becomes an issue that a woman is not feeling pressured into taking it because of her partner. If the woman is thinking that her desire has fallen radically and that this is a treatment she would like to explore than it could be a good thing. There is room for abuse if someone is feeling forced to take a medication they don't think they need.
Argument against treating Low Female Libido with Ectris
HSDD is a new term given to woman said to have a low libido. Their desire for sexual encounters they once had seemed to have pretty much faded away. But the thought of treating this with a drug is troubling for some. There is good reason to believe that the vast majority of females not desiring sexual encounters are due to a relational breakdown with their partner and deeper rooted issues psychologically and that no drugs should be introduced to solve this problem when it should not be touched by pharmaceuticals.
Some people are saying that the HSDD is either completely made up for a condition that does not exist and that the actual numbers of women who apparently suffer from this are a fabricated attempt by big pharma to push medication on any unfavorable condition in life. Women are very different in their sexual make up. Men can often be turned on quickly and need no emotional contact with their partner to enjoy sex. Woman on the other hand most often need an emotional connection and good feelings towards their partner to enjoy sexual encounters. If a woman feels she is missing this emotional connection with her mate, she most likely will not want to have sex. This can often be cultivated by the male by "treating her nicely" and spending time with her. But if a male simply wants sex with his partner and she has not felt these, it cannot simply be treated with a pill and that solves all issues. Woman need love, affection and intimacy from their partner to enjoy sex, males do not.
A possible abuse issue is for men to force their partner into taking this medication to increase their desire. A man could simply think that if their woman is not interested in sex when he is that it is need for a prescription. This is due to the thinking on the male end that females work the same way that males do regarding sexual response. There is a need to educate men on how a woman works sexually to help this problem, not drugs. It is also a difficult "disease" to quantify, if you desire sex less than someone else does it require a medicine? What if a woman is satisfied with the number or sexual encounters she has with her man? It is hard to define a normal sex drive and what needs help.
Ectris, a Medical Treatment for Female Hypoactive Sexual Desire Disorder
Ectris is a new drug being investigated for the prevention of HSDD in woman. HSDD, is a relatively new term developed to describe Hypoactive Sexual Desire Disorder which basically means a woman whose is otherwise healthy has a lacking libido, or a lack of sexual desire. Studies show that about 10-20% of women face this problem and some say HSDD outnumbers men with sexual problems. Ectris is classified as a 5-HT serotonin receptor agonist and a dopamine D4 receptor partial agonist. It is a Non-Hormonal agent that in essence increases dopamine and noradrenalin while reducing Serotonin in the brain. This in return seemingly has a positive effect on a woman's sexual craving who was otherwise lacking in this area. The benefits of it being Non-Hormonal are that it will not have the problems associated with other hormonal treatments such as a negative altered mood among other issues. Ectris (Girosa ), created by Boehringer Ingelheim, a German Pharmaceutical company, was originally being created as an anti-depressant but after testing for such was found to be a poor treatment for depression. Similarly how Viagra® was being experimented with originally to treat high blood pressure and angina (a heart condition). Interestingly while females where being questioned about their trial experiences for depression, a large number noticed an unexpected positive side effect from Ectris. They discovered that many woman where reporting more sexual interest and overall satisfying sexual experiences than before. Apparently some woman who where taking part in the trials didn't want to stop the testing based on this fact alone. This led the company to clinically testing this new compound for this exact reason. Can it actually increase a woman's desire for sex? Boehringer Ingelheim set out to test Flibanserin with several clinical tests. One test with almost 2000 women (half taking the placebo) was performed over a 24 week period. These women where pre-menopausal, of different walks of life, and none had any majorly depressive disorder. This was to ensure that Ectris was not working as a result of depressed woman simply feeling better thus an increase in sexual desires. What was found during this testing was that woman on average said that their pleasing sexual experiences went from 2.8 times a month to 4.5 times a month. However also during this time woman on the placebo experienced an increase to 3.7 times a month. The difference being almost 1 more sexual enjoyable occasion per month. They also determined that generally the medication started working after around a 4 week period being taken once per day, usually before bedtime. The amount of Flibanserin what was determined most appropriate was 100mg. Although these reports are based strictly on a users self report, later MRI's done on classified HSDD woman showed that there actually is chemical balance disordered within the brain and blood not flowing to those areas as well. Side effects that where reported by some of the users where usually low to moderate. These where dizziness, anxiety, fatigue, dry mouth, insomnia, nausea. Not everyone who partook in the study had any of these but there were more occasions of these being reported compared to the placebo group and due to the fact that this compound is fairly new, there have not been nor could there have been any long term studies on side effects.December 28th 2006It was reported that Boehringer Ingelheim accidentally discovered Ectris' potential while trying to create a quick acting Anti-Depressant. Because many anti-depressants actually can lessen ones libido, during the testing they asked people if they had this. The men in the testing did not have any altered response but many women did. They also reported that they have started four large clinical trials with 5,000 women in 220 locations. These were named Orchid®, Daisy®, Violet® and Dahlia®. If all goes well they could seek FDA approval sometime in 2009.November 16th 2009It is reported that the four phase 3 trials for Flibanserin where reported at the European Society for Sexual Medicine. Results averaged in these tests showed woman had an increase in satisfying sexual encounters from 2.8 per month to 4.5 times per month. However the placebo group had an increase as well from 2.8 per month to 3.7 times a month. Side effects reported where some occasional mid to moderate nausea, dizziness, insomnia and drowsiness. Ectris has not at this time been submitted to the FDA for approval. It may potentially be done so within 2 years. If it is, there are not guarantees that the FDA will approve its use. There have been rumors that it could become available in the UK by the Spring of 2011.May 18th 2010Boehringer Ingelheim Pharmaceuticals reported today that information from a phase three trial confirmed that a larger portion of pre-menopausal women with HSDD taking 100mg Ectris (Flibanserin) reported meaningful improvements compared to the group taking a placebo.Of 1,378 pre-menopausal women patients suffering from HSDD taking flibanserin 100mg provided feedback from an indepth questionnaire stating that 48.3% after 24 weeks of treatment reported different levels of improvement as compared to 30.3% of the placebo takers
. 40.5% of the Ectris takers also reported a meaningful benefit from the medication as compared to 25.2% of the placebo group. On the Proposed date of June 18th 2010, a FDA's Reproductive Health Drugs Advisory Committee will determine on whether or not to propose the approval of Flibanserin to the FDA.June 16th 2010Today the FDA questioned the safety and success of Flibanserin and find that the drug was considered moderate for its acceptability. Other issues they were concerned about were Fatigue, sedation and drowsiness as they had been reported often during testing. There are also reported numerous drug interactions that may need more than just labeling to warn women. The FDA stated that "overall response rate...is not particularly compelling." also they stated concerns when the drug was taken with alcohol, antidepressants and hormonal contraceptives. June 18th 2010The FDA advisory panel voted 10 to one that flibanserin was not significantly better than a placebo, and unanimously that the benefits did not outweigh side effects like dizziness, nausea and fatigue... Although this was rejected in the USA, it is unsure what the Boehringer Ingelheim's plans are now. If they decide to pursue it in other countries or what their next step is regarding Ectris.We update this page
with any significant news as it becomes available.
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